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17 However, among three important intracellular redox systems such as NADPH/NADP, thioredoxin red /thioredoxin ox and GSH/oxidized glutathione (GSSG), cellular GSH levels are 1000-fold higher than other redox couples

These results suggest that RRM2 may affect the cycle progression of thyroid cancer cells mainly by regulating the transition from G1 to S phase

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