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Most clinical studies assess outcomes at 24 weeks, with continued improvement typically observed through 12 to 24 months of use

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Wu Song, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Even at low doses, there is a theoretical risk that the blockage of opioid receptors can reduce the effect of opioid agonists to varying degrees