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J.SteenkampJ.et al

We recently repurposed sertraline, an antidepressant that efficiently crosses the BBB, as a specific SHMT1/2 inhibitor with robust anti-cancer properties, effectively targeting ser/gly-dependent cancers in vitro and in vivo [33,34,35]

The math does not change based on body weight, only the target dose changes

You might not necessarily feel that right away in the office or with the very first one or even the second one but it is very common for patients to tell us this