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Similar to the in vitro results, LC dose-dependently inhibited HDAC activities in these cultured cancer cells as well (Fig

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All statistical analyses were conducted using the TwoSampleMR (for extracting genetic associations where publicly available and harmonization), MendelianRandomization and MRPRESSO (for deriving MR estimates), and meta package (for assessing heterogeneity in sex differences) in R (version 4.0.1, R Foundation for Statistical Computing, Vienna, Austria)

Briefly, RNA from atria tissues was extracted using TRIzol reagent (Accurate Biology, Changsha, China)