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Furthermore, this study discovered that the inactivation of DHODH could sensitize GPX4 high cancer cells to ferroptosis inducers, and potentiate ferroptosis in GPX4 low cancer cells

(2010) Glutathione reductase-null malaria parasites have normal blood stage growth but arrest during development in the mosquito

In the case of Listeria monocytogenes , the bacteria sense host methylgloxyl, resulting in the bacterial production of glutathione that activates the master virulence gene regulator PrfA (1416)

This is in line with a phenotype associated to a neuron-specific knockout of the Trsp gene, which induces abnormal neuronal development and progressive neurodegeneration (Wirth et al., 2010)