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Fluorescence intensity increased over time, with the highest accumulation in the lungs, followed by the liver, and comparatively lower levels in the kidneys at all time points (Fig S5A)

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The activation of AHR caused the upregulation of GLP-1 and IL-22 at proteins and mRNA levels, decreased systemic LPS, improved gut barrier function, activated the hepatic STAT3/IL-22R/peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) and pancreatic GLP-1R/p-CREB signaling pathways, and improved lipid metabolism and insulin resistance

J., Goebel, H., Alvarez Salinas, G