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Bindoff LA, Birch-Machin M, Cartlidge NE, Parker WD Jr, Turnbull DM

Digestive health

Moreover, napabucasin is bioactivated directly by the tricarboxylic acid (TCA) cycle enzyme, 2-oxoglutarate (-ketoglutarate):acceptor oxidoreductase (OOR), leading to futile redox cycling and sustained generation of bactericidal levels of endogenous ROS