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doi: 10.3390/biology13110936

Key structural alterations include disrupted mitochondrial morphology, severe ultrastructural damage, and depletion of mitochondrial DNA (mtDNA)

This definition of oxidative stress implies that cells have intact pro-oxidant/anti-oxidant systems that continuously generate and detoxify oxidants during normal aerobic metabolism

As long as the uncontrolled water losses are less than the blowdown requirements, it does not impact the scaling tendency and programmed blowdown will still control overall water concentration