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Interestingly, in human HCC with poorer prognosis (HCCP), higher MAT1A:MAT2A switch, CpG methylation, and histone H4 acetylation were found in human HCC with a better prognosis (HCCB) [33]

Additionally, a recent meta-analysis concluded that occupational Mn overexposure is linked to lower cognitive performance, including deficits in memory, attention, and processing speed (Vlasak et al., 2023)

In aging, pathological mechanisms triggered by increased IOP will affect neuronal tissue which is less resistant to glaucomatous damage (Burgoyne, 2011)