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Interestingly, ROS generated by XO appears to be involved in the regulation of exercise-induced mitochondrial biogenesis via peroxisome proliferator-activated receptor- coactivator-1 (PGC-1) [33]

ANTIOXIDANTS 12 (7), 1351

The size of the dose also will be determined by the existence, nature, and extent of any adverse side- effects that accompany the administration of a particular vector, or transduced cell type in a particular patient