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Interaction of the PAS B domain with HSP90 accelerates hypoxia-inducible factor-1 stabilization

2), and they both use the bound GTP to time their active signaling life time

However, when activated by various pathological stimuli, including neurodegeneration, microglia can adopt a proinflammatory phenotype, leading to the release of cytokines, chemokines, and other mediators that perpetuate inflammation and contribute to neuronal loss [37,38]