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Both infected cells crossing the compromised blood-brain barrier and virions and exosomes containing viral genetic material can activate microglia via TLR3 and TLR2 receptors (191, 194)

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doi: 10.1007/s43032-023-01165-4 366 Darmochwal-KolarzDKludka-SternikMTabarkiewiczJKolarzBRolinskiJLeszczynska-GorzelakBet al

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These alterations impair NRF2 degradation and result in sustained activation of its transcriptional program

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