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If the amount of water inside a cell falls to a value that is too low, the cytosol becomes too concentrated with solutes to carry on normal cellular activities

Freezing risk is highest in these situations: placing the vial against the back wall of a cold refrigerator, storing it in a mini-fridge with poor temperature control, leaving it in a car during winter, and shipping without adequate insulation during cold months

Retrograde Mitochondrial-Nuclear Signaling One interesting feature of MOTS-c biology is that MOTS-c seems to travel to the nucleus of cells under conditions of stress and alter the expression of nuclear genes that control antioxidant defences as well as metabolic programs

2017;66:A610