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Primary bronchial epithelial cells, collection, storage, and use of tissue were performed in agreement with the Code for Proper Secondary Use of Human Tissue in the Netherlands ( The scientific board of the MPTC approved the use of materials for the present study under MPTC2010-019

Exp Ther Med (2015) 10(4):14606

This includes the one-electron reduction of Dox into its semiquinone form by P450 reductase enzymes, two-electron reduction into the alcohol metabolite doxorubicinol by carbonyl reductase enzymes, reduction into doxorubicin 7-deoxyaglycone by the action of cytosolic NADPH-dependent glycosidases, and hydrolysis by NADPH-dependent microsomal oxidoreductases into doxorubicin hydroxyaglycone (Fig

Kantarjian HM, O'Brien SM, Keating MJ, Cortes JE, Giles FJ, Beran M, Koller CA, Andreeff M, Kornblau SM , Pierce SA, Murphy S, Freireich EJ