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The pivotal role that IGF-1 plays in cell growth and proliferation, combined with the apparent protection against post-natal development of malignancies conferred by congenital IGF-1 deficiency, suggests a possible involvement of IGF-1 in the development of cancer [48]

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Results Crystallographic structures of CstB CstB is a multidomain oligomeric enzyme, consisting of the N-terminal non-heme-Fe(II) persulfide dioxygenase (PDO) domain, a middle pseudorhodanese homology domain (RHD), and the C-terminal rhodanese or sulfurtransferase domain (Rhod)