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The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron

Peptides work systemically rather than locally, but their mechanisms may preferentially affect certain fat deposits based on metabolic characteristics

doi: 10.1046/j.1471-4159.1996.67031014.x

In both reconstructed bacterial systems and human cells, luciferase translated from -modified mRNA exhibited a 20-fold higher error rate compared to uridine-containing controls [198]