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Finally, metabolic regulation provides an additional protective layer, particularly in conditions such as PCOS and diabetic erectile dysfunction (ED) (195, 196)

Methods: Atp7b IEC mice were generated using B6.Cg-Tg(Vil1-cre)997Gum/J mice from the Jackson Laboratory and Atp7b Lox/Lox mice

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In studies of rat neurons, the absence of either the regulatory or catalytic subunit of GCL led to cell death in the presence of nitric oxide or glutamate (two neurotransmitters), suggesting particular importance in neuronal cells (Maher 2006)