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Homozygous mice showed abnormal tau phosphorylation and intraneuronal A accumulation in the hippocampus and cerebral cortex at 8 months, with heterozygotes exhibiting slight A accumulation at 24 months

However, therapeutic doses for treating deficiency range from high-dose oral supplements (1,0002,000 g daily) to intramuscular injections of 1 mg, particularly for pernicious anaemia or malabsorption conditions

[DOI] [PMC free article] [PubMed] [Google Scholar] 174.Tchernof A, Belanger C, Morisset AS, Richard C, Mailloux J, Laberge P, et al

However, novel advances have led to more stable and orally bioavailable preparations that may augment this peptides already considerable therapeutic potential, especially as it affects the GI tract