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Early studies demonstrated that GDH1 must be in its catalytically active conformation to mediate NCR, functioning as a nitrogen sufficiency sensor that represses alternative nitrogen catabolic pathways independently of glutamate levels [91]

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With the advancement of metabolic mechanisms, researchers have gradually realized that, rather than solely acquiring energy, tumor cells primarily generate a diverse array of metabolites to support biosynthesis and cellular functions, such as proliferation and metastasis

A formal ASD diagnosis in Panama is never a single-clinician process