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Luciferase activity was very strong in the hypothalamus, thalamus, and pituitary gland (Fig

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Consequently, disruption of mitochondrial transport to the synapse is a primary driver of synaptic degeneration and eventual neuronal death ( Evidence from cellular and murine models indicates that Tau overexpression and hyperphosphorylation severely disrupt the localization and distribution of mitochondria ( Similarly, iPSC-derived neurons with the N279K and P301L Tau mutations show a significant reduction in anterograde axonal transport compared to healthy controls ( 5.3 ROS-driven amplification loops Mitochondrial dysfunction is an early-stage hallmark of AD, characterized by diminished ATP synthesis and a reciprocal surge in reactive oxygen species (ROS) (89)