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Additionally, we have also added one-time and annual burden estimates for Chief Executives in response to comments on the Modification to the MRF Affirmation Statement section of the CY 2026 OPPS/ASC proposed rule, addressed in an earlier section of this final rule with comment period, that suggested we failed to account for the burden for the hospital chief executive officer, president, or senior official designated to oversee the encoding of true, accurate, and complete data in the MRF to review and attest to the information

This interaction between cell aging and NAD+ reduction shows a vital link where SASP-triggered increase in CD38 disrupts cellular NAD+ balance

and (2) A new or revised code is necessary to preserve the scientific validity of such a study, such as by preventing the unblinding of the study

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