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Other funding sources: National Institutes of Health (GM103444, R.A.N

2013 Dec 15;141(4):3335-40

This was claimed to be associated with the enhancement of antioxidant defense in the liver ( Hyperhomocysteinemia is known to induce ER stress, which can activate sterol regulatory element-binding proteins (SREBPs) and upregulate enzymes in lipid synthesis, contributing to triglycerides and cholesterol accumulation and also induces apoptosis ( 4.3.2 Non-alcoholic liver disease In an early pilot study, the non-alcoholic steatohepatitis (NASH) patients who received betaine anhydrous oral solution at a dose of 20 g/day for 1 year resulted in a significant improvement in liver biochemistry and histology