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By preferentially promoting cAMP-mediated intracellular pathways, thought to be central to insulin secretion and appetite regulation, this receptor bias may enhance metabolic efficacy while potentially reducing the activation of alternative signalling cascades associated with receptor desensitisation or adverse effects (although the clinical relevance of this remains to be fully established)

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Some individuals may have difficulty maintaining sufficient vitamin D levels due to limited sun exposure, dietary factors, or certain gastrointestinal conditions that may affect nutrient absorption

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