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Notably, the methylation levels of certain genes are significantly correlated with age of onset and disease duration

The in vivo spin trapping and electron paramagnetic resonance (EPR) spectroscopy revealed that cysteine deficiency significantly increased lipid-derived radicals in BAT with undetectable signals in white adipose tissue (WAT) (Fig

These modifications occur at four key positions: position 2 prevents DPP-IV cleavage, position 8 reduces asparagine rearrangement, position 15 enhances bioactivity, and position 27 prevents methionine oxidation

The condition usually clears up gradually over the course of weeks to months