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J Pharmacol Exp Ther (2007) 323(3):787e793

As seen in AgRP GHR KO mice, GHR ablation in LepR-expressing cells prevented the F.R.-induced suppression of UCP-1 expression in the brown adipose tissue (BAT

thus, TFEB regulates redox homeostasis via targeting Nrf2 (Li et al., 2021b)

A small amount of the drug is metabolized via the cytochrome P-450 pathway (to be specific, CYP3A4 and CYP2E1) into NAPQI, which is extremely toxic to liver tissue, as well as being a strong biochemical oxidizer