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Furthermore, Research indicates that iron accumulation occurs in both acinar cells and pancreatic islet -cells in iron-loaded human pancreatin [49,50,51]

Therefore, directing CDK5 to the nucleus or exporting tumor-suppressive nuclear substrates to the cytoplasm may be promising approaches to combat CDK5-induced oncogenicity, analogous to neurotoxicity triggered by nuclear CDK5

ESMO World Congress on GI Cancer 2017 28(suppl_3), 2017

Contrary to alternative method based on a competitive hypothesis, GSVA is based on self-contained null hypothesis which analyzes each gene set in isolation, assessing differential expression of the gene set without comparing to a background [62, 63]