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GI disease, food allergies, age, stress, and taking drugs and or medications can cause a decrease in activity of any of these, and therefore will lead to B12 deficiency

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Adding a low-dose SERM when using Kisspeptin-10 may be particularly helpful during the first two weeks of PCT when suppression is typically most severe

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However, successful clinical implementation will require deeper mechanistic insight, optimized therapeutic strategies, and comprehensive safety profiling (149, 154)

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