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Beyond drug sensitization, palmitoylation also intersects with the DDR, where loss of ZDHHC8 impairs G2/M checkpoint activation, inducing CIN and enhancing radiosensitivity [177]

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Re-expressing cell lines of HMOX2 WT, HW/GW mutant, or K68R mutant were analyzed by immunofluorescence with anti-HA, anti-Calnexin, and anti-Tom20 antibodies to visualize the localization of HMOX2, ER, and mitochondria, respectively

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