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Glossary APC Adenomatous polyposis coli ALOX15 Arachidonate 15-lipoxygenase ADMA Asymmetric dimethyl arginine CHAC1 Cation transport regulator homolog 1 CTCs Circulating tumor cells CBS Cystathionine -synthase CSE Cystathionine -lyase COX-2 Cyclooxygenase-2 DDAH1 Dimethylarginine dimethylaminohydrolase 1 eNOS Endothelial nitric oxide synthase EMT Epithelialmesenchymal transition ERK Extracellular signal-regulated kinases EVs Extracellular vesicles GAPDH Glyceraldehyde-3-phosphate dehydrogenase GLS2 Glutaminase 2 GPX4 Glutathione peroxidase 4 CAT1 High-affinity cationic amino acid transporter 1 H 2 S Hydrogen sulfide iNOS Inducible nitric oxide synthase IFN- Interferon-gamma IL-6 Interleukin-6 Substrate for nitric oxide synthesis L-arginine MAPK Mitogen-activated protein kinases MDSCs Myeloid-derived suppressor cells NOX4 NADPH oxidase 4 nNOS Neuronal nitric oxide synthase NO Nitric oxide NOS Nitric oxide synthase PPP Pentose phosphate pathway ONOO Peroxynitrite PDE2A Phosphodiesterase 2A PDE5A Phosphodiesterase 5A PRMT1 Protein arginine methyltransferase 1 PRMT5 Protein arginine methyltransferase 5 PKG Protein kinase G RNS Reactive nitrogen species ROS Reactive oxygen species SNO S-nitrosylation sGC Soluble guanylate cyclase TMEM180 Transmembrane protein 180 TAMs Tumor-associated macrophages TNF- Tumor necrosis factor-alpha VEGF Vascular endothelial growth factor References 1

Food Biosci 43:101297 Zhu JX, Yang HY, Hu WQ, Cheng J, Liu Y, Yi LT, Cheng HY (2021b) Active components from Lagotis brachystachya maintain uric acid homeostasis by inhibiting renal TLR4-NLRP3 signaling in hyperuricemic mice

Maduni, J., Maduni, I

Despite its wide use, optimal dosing to achieve efficacy and minimize toxicity remains problematic