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SESN2 also decreases iron deposition and reverses the elevated expression of ACSL4 and TFR1 while enhancing the expression of SCL7A11 and GPX4, thereby inhibiting ferroptosis

[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Andrade F.H., Reid M.B., Allen D.G., Westerblad H

Additionally, cyclin dependent kinases (CDKs) are also key regulators of DRR, which led to a phase I study examining the combination of ribocliclib, a CDK4/6 inhibitor, with carboplatin/paclitaxel in patients with recurrent platinum-sensitive ovarian cancer (NCT03056833) [85]