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Stepien -- which, ironically, even includes one of the lead investigators of the EPIC Study and three other participating clinicians in the study), recommends starting pimobendan on symptomless MVD-affected dogs only if the dogs' cardiac enlargement is "substantial"

ENO1 is crucial to glucose metabolism

Narasaiah et al

For instance, Epstein and colleagues [90] defined a conserved HIF-pVHL-prolyl hydroxylase pathway in Caenorhabditis elegans and used a genetic approach to identify EGL-9 as a dioxygenase that regulates HIF by prolyl hydroxylation