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Culturing with anti-human KITLG neutralizing antibody [37] for 4 days inhibited the proliferation of GIST-T1 cells by ~40% (IC 50 : ~9 ng/mL) and GIST-T1-5R cells by ~34% (IC 50 : ~26 ng/mL) (Figure 1B), whereas the same treatment had no effect on KIT + GIST882 and KIT low/ GIST48B cells lacking WT KIT allele or on KIT - LX-2 cells