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J Clin Endocrinol Metab 81:33523359 Vaccarello MA, Diamond FB Jr, Guevara-Aguirre J, Rosenbloom AL, Fielder PJ, Gargosky S, Cohen P, Wilson K, Rosenfeld RG (1993) Hormonal and metabolic effects and pharmacokinetics of recombinant insulin-like growth factor-I in growth hormone receptor deficiency/laron syndrome

52 Overall, GTP is suggested as a safer alternative for patients with KOA, particularly those with cardiovascular and gastrointestinal comorbidities, due to its lower incidence of gastrointestinal adverse events compared to NSAIDs