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Neurons are highly vulnerable to oxidative damage due to their high metabolic rate and limited capacity for regeneration (Cobley et al., 2018)

Collectively, adequate SCFA, particularly butyrate, production by a eubiotic microbiota represents a key mechanism through which the gutbrain axis maintains redox balance and neuronal health

However, if any side effects persist or worsen, consulting a doctor is advisable

We will continue to consider ways to minimize program disruptions for ACOs that could result from one or more reopenings, to the extent feasible, and to reduce operational burdens for both ACOs and CMS that could result from making payment adjustments, as reflected in the discussion in the CY 2025 PFS proposed rule (89 FR 61896 through 61897), and earlier rulemaking (see for example, 81 FR 38001 through 38002