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While the complex relationship between CFTR dysfunction and oxidative stress, as well as the clinical outcomes of antioxidant therapies, have been discussed at length in numerous excellent reviews (Galli et al., 2012

N Engl J Med 336:633640 Foncea R, Andersson M, Ketterman A et al (1997) Insulin-like growth factor-I rapidly activates multiple signal transduction pathways in cultured rat cardiac myocytes

This is supported by studies in which humans were exposed to tracer levels of radioiodine as either I 2 or methyl iodide, and in studies in which monkeys inhaled particulate aerosols of sodium iodide (Black and Hounam 1968