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PROTACs, heterobifunctional molecules comprised of functional ligands for POI and E3 ligases that are bridged by a linker, offer robust protein degradation/inhibition efficacy surpassing small-molecule inhibitors 35 , primarily owing to their catalytic nature 36

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The bone marrows trabecular framework, surrounded by endosteum covered with osteoblasts and osteoclasts, includes a network of sinusoidal capillaries that facilitate the movement of DTCs in and out of circulation

Priority was given to studies that included quantitative antimicrobial endpoints (e.g., MICs, biofilm assays), mechanistic validation (e.g., thiol modification, redox perturbation, signaling pathway engagement), in vivo infection or inflammation models, or human PK/PD or biomarker data