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164 In addition, some nonselective or selective agents against NLRP3 inflammasome including melatonin (NCT04409522), OLT1177 (NCT04540120), aai palm berry extract ( Euterpe oleracea ) (NCT04404218), and ZYIL1 (selective inhibitor) (NCT04731324) are under investigation

The main pathological changes in psoriasis include excessive keratinocyte proliferation, epidermal hyperplasia, and increased neoangiogenesis, accompanied by inflammatory cell infiltration (Luo et al., 2020