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Its immune-modulating properties have attracted considerable interest among clinicians seeking supportive therapies for individuals with recurrent infections or impaired immune function

Through metagenomic sequencing and in vitro coculture experiments of peripheral blood mononuclear cells (PBMCs), it was verified that butyrate can selectively expand peripheral blood Tregs in RA patients, inhibit the activation of conventional T cells (Tconvs), downregulate the production of anti-citrullinated peptide antibodies (ACPA), and reduce cartilage and bone tissue damage

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Patient understanding correlates with adherence, suggesting that patient education and knowledge reinforcement may be key to adherence with VB12 supplementation