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Bush and independent businessman Ross Perot in the 1992 presidential election

[4] Catalytic mechanism During the reaction, the sulfhydryl group of coenzyme A performs a nucleophilic attack on the carbonyl carbon of the acetyl group of acetyl-dihydrolipoamide (bound to dihydrolipoyl transacetylase)

Other enzyme defects in the heme biosynthesis pathway are associated with porphyria, classified as either erythropoietic or hepatic based on the site of intermediate product accumulation 188