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6 Conclusion The clinical significance of SLC7A11 as a therapeutic target is substantial due to its role in essential processes like response to oxidative stress and the regulation of cell death

93 OhnumaT.NakayamaS.AnanE.NishiyamaT.OguraK.HiratsukaA

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If oxidation of lens constituents is indeed an initiating factor in cataract development, the potentially harmful species of oxygen responsible for the damage are superoxide, hydrogen peroxide, and the hydroxide radical.192 There is some evidence that the concentration of hydrogen peroxide is elevated in the aqueous humor of some patients with cataract.193 The source of hydrogen peroxide in the eye is uncertain, but ascorbic acid, present at normally high concentrations in the aqueous humor, can be a source of hydrogen peroxide in the presence of light and a metal ion