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In summary, by integrating high-content single-cell level imaging analyses with mechanistic studies, extensive preclinical therapeutic experiments and a Phase Ib clinical trial, our studies herein elucidate the AR +/- BCL-2 +/- PCa cell subpopulation dynamics and credentials BCL-2 as a vital therapeutic target in heterogeneous CRPC

Sodium DNA is essential for DNA metabolism, upon which cell repair and tissue regeneration processes are based

Vitamin B12 appears in the milk of nursing mothers in concentrations that approximate the mother's vitamin B12 blood level

Maximum treatment duration: suitable for long-term use as a supplement unless otherwise directed