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[3] Researchers report that 65% of [research models] receiving GH achieved remission, compared to 20% [given] CTX alone. Growth hormone appears to act via Vasoactive Intestinal Peptide (VIP) receptor VIPC1

10.1371/journal.pone.0077189 119 WidodoN.KaurK.ShresthaB

Systematic Review and Meta-Analysis. 2025

Indeed, psychological (e.g., anxiety, depression, and stress [6]), hormonal (e.g., hypogonadism, hypothyroidism, hyperprolactinemia [7]), cardiovascular (e.g., hypertension, atherosclerosis, heart failure [8]), metabolic (e.g., obesity, metabolic syndrome, diabetes, dyslipidemia, gout [9,10]), neurologic (e.g., central and peripheral neuropathies [11,12,13]) risk factors can promote the development of ED [14], or its progression from subclinical to more severe forms [15]