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Formerly, focal/grid laser photocoagulation was the standard treatment option for DME, which primarily targets the macula

10.1038/s41598-018-30834-7 267

Oxidative stress can damage reproductive cells and decrease fertility potential

In this section, we discuss the pathways through which specific nutrients inhibit epigenetic enzymes such as DNMTs, HATs, and HDACs, thereby impacting gene expression (Tiffon 2018)