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Detailed statistical values are provided in Supplementary Table 7

MOTS-c optimizes mitochondrial function and metabolic efficiency through AMPK activation, improved insulin sensitivity, and support for mitochondrial biogenesis

Interestingly, the reversal of the FXN gene silencing in neurons derived from patient iPSCs is comparable to that found in previous studies performed on PBMCs and in vivo models [55,56,57,58]