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1 Introduction Chlorogenic acid (CGA), also called caffeoylquinic acid (CQA), is a dietary polyphenol formed by the esterification of caffeic acid (CA) and quinic acid (QA) ( in vitro , and at 25 M, it reduces reactive oxygen species (ROS) to alleviate oxidative stress in intestinal cells ( eucommia , honeysuckle , and green tea ( The liver is vital for metabolism, the endocrine regulation, and immune response but is often exposed to irritants like viruses, medications, and chemicals ( Building on the aforementioned research findings, we propose the hypothesis that an optimal concentration of CGA confers protection to liver cells via its antioxidant properties

In 1977, Schlesinger, Pickart and Thaler reported in Experientia that the growth-modulating activity previously observed in human serum came from this specific tripeptide (PubMed 858356)

Butler PC, Chou J, Carter WB, Wang YN, Bu BH, Chang D, et al

JXGG-2021244459 and 2021255537), and the Gansu Provincial Public Health Research Project for Disease Control and Prevention (No