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This deficiency persisted unless the cells were primed with exogenous cytokines, indicating that cannabis-induced suppression of intrinsic cytokine priming mechanisms significantly hampers the antimicrobial efficacy of AMs (74)

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Complementing previous findings activation of D 2 receptors (e.g., apomorphine, amphetamine, quinpirole and SKF82958) led to an increase in GH and a decrease in triiodothyronine (T 3 ) in the pituitary, which led to induction of CYP2B, CYP2C11, and CYP3A and inhibition of CYP1A