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World J Gastroenterol

In this study, using actual low-nicotine tobacco, that compensation didnt occur

The odds ratio (OR) for TT was 1.69 (adjusted) and 1.64 (unadjusted), while for FT, it was 1.27 (adjusted) and 1.32 (unadjusted)

Pros, Cons, and Who They're Best For Pros: Highest clinical success rates of any cessation method (varenicline has a 33% quit rate at 6 months according to Cochrane reviews [9]), no nicotine intake, addresses the neurochemical root of addiction Cons: Requires doctor's prescription, potential side effects (nausea, vivid dreams, mood changes), not suitable for everyone, supply issues in some regions Best for: Heavy, long-term nicotine users who've tried other methods without success, and those with strong physical dependence 8