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Research has shown that these chemicals include: Benzene, which is found in car exhaust Heavy metals, such as lead Diacetyl, a chemical that can cause lung disease Formaldehyde, a human carcinogen also found in car exhaust Acrolein, which contributes to permanent lung damage Some research has shown inhaling e-cigarette fluids that contain nicotine triggered effects that a doctor would expect to see in someone with COPD, including destruction of lung tissue