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1 series f20 2010-2016 2 series f44 2018-204 3 series e90 2006-2012 3 seires f30 2012-2018 3 seirs gt f34 2012-2018 3 seires g20 2018-2024 5 series e60 2006-2010 5 series f10 2010-2017 5 series g30 2018-2023 5 series g60 2024+ 6 seies e63 2006-2012 6 series f12 2012-2016 6 series g32 2016-2024 7 series f02 2009-2016 7 series g12 2016-2023 7 series g70 2023+ x1 e84 2010-2016 x1 f48 2016-2024 x1 u11 2024 x3 f25 2010-2017 x3 g01 2018-2024 x4 g02 2018-2024 x5 x6 e70 2006-2014 x5 x6 f15 20015-2019 x5 x6 g05 2020-2024 x7 g07 2018-2024 m2 g87 2020 xm 2020 z4 e89 2010-2016 z4 g29 2017-2024 E60 E66 E70 E71 E90 E92 E84 E89 F02 F06 F07 F10 F12 F20 F25 F30 F34 F44 F60 F80 F90 G12 G01 G02 G08 G20 G28 G30 G38 G60 G80 G90 G05 G06 G07 G28 G29 cigarette cigar lighter smoke

1 Introduction Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory disorder with a global prevalence of 10.3% and an estimated 392 million patients worldwide ( Cigarette smoking is the major risk factor for COPD in the Western world ( The lung harbors different subsets of macrophages, including interstitial macrophages that are present in the lung interstitium between blood vessels and alveoli whereas alveolar macrophages (AM) are found in the alveolar space and airspace ( Single-cell genomics technologies, particularly single-cell RNA-sequencing (scRNA-seq), now allows a detailed characterization of such complex cell communities and their molecular mechanisms