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As part of the FDAs scientific review, the agency considered whether smokers who switch to reduced nicotine cigarettes would either smoke more cigarettes or change the way they smoked, such as taking a bigger puff, in order to get the same level of nicotine they would have from smoking conventional cigarettes

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Furthermore, we measured hydroxylated HIF-1 levels under the same conditions as a measure of hydroxylation by PHDs and subsequent degradation, which was significantly upregulated after 4 h (Fig